Antônio Carlos Joussef


Area: Organic Chemistry
Phone: (48) 3721-6847 x.246 Fax: (48) 3721-6852 x.254
Office: QMC 304
Research Group:
Curriculum Lattes: Research Group website
Bio: Ph.D., University of Alberta, Canada, 1990.


Current lines of research

Glutarimide alkaloids: The synthesis of natural products containing the glutarimide ring that have pharmacological properties.

Free Radical Chemistry: The development of free radical methodology for making diketopiperazines using L-proline as a chiral building block. [texto diferente da página em português]

Histidyl-hydrazides as scavengers of reactive carbonyl compounds (RCCs): The synthesis of histidyl-hydrazide carnosine analogs as scavengers of 4-hydroxynonenal (4-HNE).

Desenvolvimento de uma metodologia sintética na preparação de dicetopiperazinas derivadas da L-prolina como bloco construtor de compostos de interesse farmacológico via radical livre.


Selected Research Publications
SILVA, Luiz Everson da, JOUSSEF, A. C., NUNES, Ricardo José, OLIVEIRA, K. N. Synthesis of 1,8-Naphthyridine-4(1H)-one Sulfonamides by Thermolysis of 2-Aminopyridinemethylene (Meldrum's Acid) Derivative. Synthetic Communications. , v.38, p.15 - 20, 2008. DOI: 10.1016/j.bmc.2007.09.007
JOUSSEF, A. C., SILVA, Luiz Everson da, PACHECO, Leticia Kramer, Daniela Gaspar da Silva, STEINDEL, Mario, REBELO, Ricardo Andrade Synthesis and in vitro evaluation of leishmanicidal and trypanocidal activities of N-quinolin-8-yl-arylsulfonamides. Bioorganic & Medicinal Chemistry. , v.15, p.7553 - 7560, 2007. DOI: 10.1016/j.bmc.2007.09.007

JOUSSEF, A. C., SILVA, Luiz Everson da, REBELO, Ricardo Andrade, STEINDEL, Mario, PACHECO, Leticia Kramer, DUARTE, Anita Mauricio Camila, ALBINO, Danielle Bibas Legat

Synthesis and antiparasitic activity against Trypanosoma cruzi and Leishmania amazonensis of chlorinated 1,7- and 1,8-naphthyridines. Letters in Drug Design & Discovery. , v.4, p.154 - 159, 2007. DOI: 10.2174/157018007779422550

JOUSSEF, A. C., SOUZA, Luciana de B P de, MEYER, Emerson Synthesis of New 1,2,4- and 1,3,4-Oxadiazole Derivatives as Potential Nonpeptide Angiotensin II Receptor Antagonists. Synthetic Communications. , v.36, p.729 - 741, 2006. DOI: 10.1080/00397910500447066