Prof. Dr. Ademir Neves

Field: Inorganic Chemistry
Phone: (48) 3721-6847 x.219 Fax: (48) 3721-6852 x.254
Office: QMC 219
seta marca_lattes
seta Research Group website
Bio: Ph.D., Universität Bochun, Germany, 1983.

Current Research

Bioinspired Models of Small Molecules for the Active Site of Metalloenzymes and Hydrolases/Nucleases: Our current interest in this research area is related to the design of unsymmetrical small molecules as synthetic and functional models for the active site of metalloenzymes, including catechol oxidases and purple acid phosphatases. The research also includes the application of these transition metal complexes as tools to probe recognition and reactions of double helical DNA and the design of novel chemotherapeutics.Anchored Functionalized Nanomaterials as Tools for Synthetic Nucleases and Proteases and their Biomedical and Catalytic Applications: There is a great interest in our group in the synthesis and characterization of dinucleating ligands and their unsymmetrical complexes as {MIII(m-OH)MII} and {LnIII(m-OH)2LnIII} containing suitable chemical functions (Carbonyl, ammine) to anchore covalently on the surface of materials as chitosan, silica and iron oxide covered with modified silica. The utilization of such materials in catalysis of phosphate diesters as DNA and as  efficient drug delivery systems is the major objective related to this research area.

Selected Research Publications

Schenk, G.; Peralta, R. A.; Batista, S. C.; Bortoluzzi, A. J.; Szpoganicz, B.; Dick, A. K.; Herrald, P.; Hanson, G. R.; Szilagyi, R. K.; Riley, M. J.; Gahan, L. R.; Neves, A. Probing the role of the divalent metal ion in uteroferrin using metal ion replacement and a comparison to isostructural biomimetics, J. Biol. Inorg. Chem. 13(1), 139-155, 2008. DOI: 10.1007/s00775-007-0305-z

Camargo, M. A.; Neves, A.; Bortoluzzi, A. J.; Szpoganicz, B.; Martendal, A.; Murgu, M.; Fischer, F. L.; Terenzi, H.; Severino, P. C. New Gadolinium Complex with Efficient Hydrolase-like Activity: A 100-Million-Fold Rate Enhancement in Diester Hydrolysis Inorg. Chem. 47(8); 2919-2921, 2008. DOI: 10.1021/ic702167p

Neves,A.; Lanznaster, M.; Bortoluzzi, A. J.; Peralta, R. A.; Casellato, A.; Castellano, E. E.; Herrald, P.;Mark J. Riley, M. J.;  Schenk, G. An Unprecedented FeIII(1-OH)ZnII Complex that Mimics the Structural and Functional Properties of Purple Acid Phosphatases  J. Am. Chem. Soc. 129(24), 7486 -7487, 2007. DOI: 10.1021/ja071184l

Rey, N. A.; Neves, A.; Bortoluzzi, A. J.; Pich, C. T.; Terenzi, H. Catalytic Promiscuity in Biomimetic Systems: Catecholase-like Activity, Phosphatase-like Activity, and Hydrolytic DNA Cleavage Promoted by a New Dicopper(II) Hydroxo-Bridged Complex, Inorg. Chem. 46 (2), 348 -350, 2007. DOI: 10.1021/ic0613107

Mitic´N.;  Smith, S. J.; Neves, A.; Guddat, L.W.; Gahan, L.R.; Schenk, G. The Catalytic Mechanisms of Binuclear Metallohydrolases, Chem. Rev. 1106(8), 3338-3363, 2006. DOI: 10.1021/cr050318f