Profa. Dra. Hellen Karine Stulzer

Área: Físico-Química  
Telefone: 3721 3498
Sala / Laboratório CCS Bloco J/K sala K204
Grupo de pesquisa Sistemas de liberação de fármacos
Currículo Lattes


Linhas de pesquisa
  • Desenvolvimento de sistemas de liberação de fármacos
  • Avaliação de potenciais inibidores de precipitação em sistemas supersaturados de fármacos


Publicações selecionadas

  1. ANZILAGGO, D. ; BERINGHS, A. O. ; SONAGLIO, D. ; PEZZINI, B. R.; STULZER, H. K. . Liquisolid Systems: Understanding the impact of drug state (solution or dispersion), nonvolatile solvent and coating material on Simvastatin apparent aqueous solubility and flowability. COLLOIDS AND SURFACES B-BIOINTERFACES, v. 175, p. 36-43, 2019.
  2. FRANCA, M. T. ; PINTO, J. M. O. ; RIEKES, M. K.; Rafael Nicolay Pereira ; STULZER, H . K. . Investigation of novel supersaturating drug delivery systems of chlorthalidone: the use of polymer-surfactant complex as an effective carrier in solid dispersions. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, v. 111, p. 142-152, 2018.
  3. PINTO, JULIANA MUNARI OLIVEIRA ; LEÃO, ALINE FRANCIANE ; RIEKES, MANOELA KLÜPPEL ; FRANÇA, MARIA TEREZINHA ; STULZER, HELLEN KARINE. HPMCAS as an effective precipitation inhibitor in amorphous solid dispersions of the poorly soluble drug candesartan cilexetil. CARBOHYDRATE POLYMERS, v. 184, p. 199-206, 2018.
  4. NART, V. ; BERINGHS, A. O. ; ESPINDOLA, B. ; FRANCA, M. T. ; PEZZINI, B. R.STULZER, H .  . Carnauba wax as a promising excipient in melt granulation targeting the preparation of mini-tablets for sustained release of highly soluble drugs. Materials Science & Engineering. C, Biomimetic Materials, Sensors and Systems (Print), v. 70, p. 250-257, 2017.
  5. RIEKES, M. K.; ASWIN, D. ; PHILIPPE, B. ; AUGUSTIJNS, P. ; STULZER, H . K. ; MOOTER, G. V. D. . Development of enteric-coated fixed dose combinations of amorphous solid dispersions of ezetimibe and lovastatin: Investigation of formulation and process parameters.. INTERNATIONAL JOURNAL OF PHARMACEUTICS, v. 520, p. 48-59, 2017.
  6. RIEKES, M. K.; ENGELEN, A ; APPELTANS, B ; ROMBAUT, P ; STULZER, H . K. ; MOOTER, G. V. D. . New Perspectives for Fixed Dose Combinations of Poorly Water-Soluble Compounds: a Case Study with Ezetimibe and Lovastatin. Pharmaceutical Research, v. 33, p. 1259-1275, 2016.
  7. BORBA, P. A.PEZZINI, B. R. ; PINOTTI, M. ; CAMPOS, C. E. M. ; STULZER, H . K. . Sodium alginate as a potential carrier in solid dispersion formulations to enhance dissolution rate and apparent water solubility of BCS II drugs. Carbohydrate Polymers, v. 137, p. 350-359, 2016.
  8. RIEKES, M. K.CAMPOS, C. E. M. ; Gislaine Kuminek ; BERNARDI, L. S. ; CAON, T. ; FERANDES, Daniel ; SORDI, R. ; SILVA JUNIOR, J. ; RAMBO, C. R. ; STULZER, H . K. . Enhanced hypotensive effect of nimodipine solid dispersions produced by supercritical CO2 drying. Powder Technology (Print), v. 278, p. 204-210, 2015.
  9. NART, V. ; FRANCA, M. T. ; ANZILLAGO, D. ; KRATZ, J. ; CAMPOS, C. E. M.SIMOES, C. M. O. ; RIEKES, M. K. ; STULZER, H . K. . Ball-milled solid dispersions of BCS Class IV drugs: Impact on the dissolution rate and intestinal permeability of acyclovir. Materials Science & Engineering. C, Biomimetic Materials, Sensors and Systems (Print), v. 53, p. 229-238, 2015
  10. BORBA, P. A.; OLCHANHESKI JUNIOR, L. R. ; PINOTTI, M. ; ANDRADE, G. R. S. ; COSTA, N. B. ; FERANDES, Daniel ; CAMPOS, C. E. M. ; STULZER, H . K. . The effect of mechanical grinding on the formation, crystalline changes and dissolution behaviour of the inclusion complex of telmisartan and β-cyclodextrins. Carbohydrate Polymers, v. 133, p. 373-383, 2015
  11. RIEKES, M. K.RAUBER, G. S. ; Gislaine Kuminek ; CAMPOS, C. E. M. ; BORTOLUZZI, A. J. ; STULZER, H .  . HPMC as a potential enhancer of nimodipine biopharmaceutical properties via ball-milled solid dispersions. Carbohydrate Polymers, v. 99, p. 474-482, 2014.
  12. LACERDA, L. ; LARANJEIRA, Mauro Cesar MarghettiFAVERE, V. ; PARIZE, Alexandre L ; STULZER, H . K. . Development and evaluation of pH-sensitive sodium alginate/chitosan microparticles containing the antituberculosis drug rifampicin. Materials Science & Engineering C-Materials for Biological Applications, v. 39, p. 161-167, 2014.
  13. RIEKES, M. K.Gislaine Kuminek ; GRANADA, A. ; TAGLIARI, Monika Piazzon ; SILVA, Marcos Antonio Segatto ; STULZER, H . K. . Enhanced solubility and dissolution rate of amiodarone by complexation with Beta-ciclodextrin through different methods. Materials Science & Engineering. C, Biomimetic Materials, Sensors and Systems (Print), v. 30, p. 1008-1013, 2010.
  14. STULZER, H . K.; TAGLIARE, Monika Piazzon ; LACERDA, L. ; SILVA, Marcos Antonio SegattoLARANJEIRA, Mauro Cesar Marghetti . Synthesis and characterization of cross-linked malonylchitosan microspheres for controlled release of acyclovir. Carbohydrate Polymers, v. 73, p. 490-497, 2008.
  15. STULZER, H . K.; FERNANADES, Daniel ; ASSREUY, JamilSILVA, Marcos Antonio Segatto . Development of controlled release captopril granules coated with ethylcellulose and methylcellulose by fluid bed dryer. Drug Delivery, v. 15, p. 11-18, 2008.